To avoid withdrawal symptoms, patients should slowly decrease doses of antipsychotics over months or even years

Withdrawing from antipsychotics may require months or even years, and patients need to gradually reduce to very low doses, according to a new analysis led by UCL and King’s College London academics. The review, published in Schizophrenia Bulletin, is the first-ever scientific paper outlining how exactly antipsychotic medication should be reduced in order to minimize […]

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Study of NCOA3 yields novel findings of melanoma progression

For the first time, activation of nuclear receptor coactivator 3 (NCOA3) has been shown to promote the development of melanoma through regulation of ultraviolet radiation (UVR) sensitivity, cell cycle progression and circumvention of the DNA damage response. Results of a pre-clinical study led by Mohammed Kashani-Sabet, M.D., Medical Director of the Cancer Center at Sutter’s […]

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Second drug targeting KRASG12C shows benefit in mutated non-small-cell lung cancer

Clinical activity with a second drug inhibiting KRASG12C confirms its role as a therapeutic target in patients with advanced non-small-cell lung cancer (NSCLC) harboring this mutation, according to results from a study with the KRASG12C inhibitor adagrasib reported at the European Lung Cancer Virtual Congress 2021. “As we strive to identify the oncogenic driver in […]

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